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Degraded Hyaluronic Acid-Modified Magnetic Nanoparticles.
- Source :
-
Journal of Nanomaterials . 2/11/2020, p1-8. 8p. - Publication Year :
- 2020
-
Abstract
- Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with hyaluronic acid (HA) functional groups have potential applications as cell targeting materials. However, SPIONs incubated with high-molecular weight HA can result in severe agglomeration. In this work, we found that when modified with degraded HA (hyaluronan oligosaccharides (oHAs)), the nanoparticles were uniformly dispersed with small hydrodynamic sizes, and the oHA-modified SPIONs exerted minimal cytotoxicity. With the same functional groups as HA, the oHA-modified SPIONs may have various biomedical applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16874110
- Database :
- Academic Search Index
- Journal :
- Journal of Nanomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 141684907
- Full Text :
- https://doi.org/10.1155/2020/1084890