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Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma.
- Source :
-
Journal of Cellular Physiology . May2020, Vol. 235 Issue 5, p4167-4182. 16p. - Publication Year :
- 2020
-
Abstract
- Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS‐CSCs play a key role in the resistance to treatment and relapse and metastasis through self‐renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell‐phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER stem cells
*PATHOLOGY
*TUMORS in children
*BONE cancer
*AGE groups
Subjects
Details
- Language :
- English
- ISSN :
- 00219541
- Volume :
- 235
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Cellular Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 141721702
- Full Text :
- https://doi.org/10.1002/jcp.29344