Back to Search
Start Over
Radioisotope and anticancer agent incorporated layered double hydroxide for tumor targeting theranostic nanomedicine.
- Source :
-
Applied Clay Science . Mar2020, Vol. 186, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Theranostic nanomedicine was successfully prepared using layered double hydroxide (LDH). By means of step-by-step incorporation of an anticancer drug, methotrexate (MTX), and a radioisotope, Co-57, into the interlayer space and lattice of LDH, respectively, theranostic hybrid Nanomedicine could be prepared. X-ray diffractometry, scanning electron microscopy, X-ray adsorption spectroscopy, and Fourier-transform infrared spectroscopy systematically showed that incorporating the Co2+ into the MTX-LDH did not alter the crystalline phase, size, morphology, or intact structure of the hybrid. The labeled Co-57 in MTX-LDH was highly stable in human serum, showing almost 90% retention after 48 h. In vitro cellular uptake of Co-57-labeled MTX-LDH was very high in mouse colon carcinoma CT-26 cells, with ~60 ID% at 4 h. The cytotoxicity assay of MTX-LDH showed high cancer-cell suppression on CT-26 cells. To evaluate the diagnostic ability of Co-57-labeled MTX-LDH, in vivo single-photon emission computed tomography (SPECT) images were investigated on CT-26 xenografted mouse model. The SPECT signal in tumor tissue began to appear within 1 h, and it increased for 3 h. Unlabelled Image • Theranostic nanomedicine based on LDH was successfully prepared. • The radioisotope was substituted and drug was intercalated into LDH. • The radioisotope tracer, Co-57, showed rapid contrasting effect in tumor model. • The loaded drug showed high anticancer activity through efficient delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01691317
- Volume :
- 186
- Database :
- Academic Search Index
- Journal :
- Applied Clay Science
- Publication Type :
- Academic Journal
- Accession number :
- 141731324
- Full Text :
- https://doi.org/10.1016/j.clay.2020.105454