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MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF.
- Source :
-
Artificial Cells, Nanomedicine & Biotechnology . Dec2019, Vol. 47 Issue 1, p278-289. 12p. - Publication Year :
- 2019
-
Abstract
- MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER cell proliferation
*PROSTATE cancer
*CELL proliferation
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 21691401
- Volume :
- 47
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Artificial Cells, Nanomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 141770161
- Full Text :
- https://doi.org/10.1080/21691401.2018.1553783