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Laser-patterned paper-based sensors for rapid point-of-care detection and antibiotic-resistance testing of bacterial infections.
- Source :
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Biosensors & Bioelectronics . Mar2020, Vol. 152, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
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Abstract
- Antimicrobial resistance (AMR) has been identified by the World Health Organisation as a global threat that currently claims at least 25,000 deaths each year in Europe and 700,000 globally; the number is projected to reach 10 million per year between 2015 and 2050. Therefore, there is an urgent need for low-cost but reliable point-of-care diagnostics for early screening of infections especially in developing countries lacking in basic infrastructure and trained personnel. This work is aimed at developing such a device, a paper-based microfluidic device for infection testing by an unskilled user in a low resource setting. Here, we present our work relating to the use of our laser-patterned paper-based devices for detection and susceptibility testing of Escherichia coli , via a simple visually observable colour change. The results indicate the suitability of our integrated paper devices for timely identification of bacterial infections at the point-of-care and their usefulness in providing a hugely beneficial pathway for accurate antibiotic prescribing and thus a novel route to tackling the global challenge of AMR. • A paper-sensor for infection testing by unskilled users in a low resource setting. • The three-layer device was fabricated using a laser direct-write procedure. • It enables both detection and antibiotic-resistance testing of bacterial infections. • The device can be used at point-of-care with a simple colorimetric readout. • The integrated device offers a novel route to tackling the global challenge of AMR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 152
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 141778426
- Full Text :
- https://doi.org/10.1016/j.bios.2020.112008