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Hypotonicity promotes epithelial gap closure by lamellipodial protrusion.

Authors :
Chen, T.
Zhao, H.
Gao, L.
Song, L.
Yang, F.
Du, J.
Source :
Progress in Biophysics & Molecular Biology. Nov2019, Vol. 148, p60-64. 5p.
Publication Year :
2019

Abstract

The closure of gaps within epithelia is an essential part of many physiological and pathological processes, such as embryonic development, organ remodeling and wound healing. Emerging evidence proved that the physical microenvironment plays important roles in cell behaviors. However, the effect of osmolarity of extracellular medium on gap closure is least understood. Using a gap closure model of epithelial cells, we found that hypotonic condition significantly facilitated the process of gap closure. Moreover, instead of actomyosin ring, enhanced migration leading by lamellipodia primarily contributed to the rapid gap closure in hypotonic condition. These findings provide insights for understanding the physiology of epithelial gap closure. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00796107
Volume :
148
Database :
Academic Search Index
Journal :
Progress in Biophysics & Molecular Biology
Publication Type :
Academic Journal
Accession number :
141779833
Full Text :
https://doi.org/10.1016/j.pbiomolbio.2017.09.021