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An asymmetric hydrocyanation/Michael reaction of α-diazoacetates via Cu(I)/chiral guanidine catalysis.
- Source :
-
Chemical Communications . 2/18/2020, Vol. 56 Issue 14, p2155-2158. 4p. - Publication Year :
- 2020
-
Abstract
- An asymmetric one-pot hydrocyanation/Michael reaction of α-aryl diazoacetates with trimethylsilyl cyanide, tert-butanol, and N-phenylmaleimides has been realized. Using a chiral guanidinium salt/CuBr catalyst, a series of cyanide-containing pyrrolidine-2,5-diones could be obtained in good yields with excellent diastereo- and enantioselectivities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 141804620
- Full Text :
- https://doi.org/10.1039/c9cc09521g