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替加环素鞘内注射治疗多重耐药鲍曼不动杆菌颅内感染.
替加环素鞘内注射治疗多重耐药鲍曼不动杆菌颅内感染.
- Source :
-
Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi . Feb2020, Vol. 17 Issue 1, p90-93. 4p. - Publication Year :
- 2020
-
Abstract
- Objective To explore the administration of tigecycline for intracranial infection of multiple drug resistant Acinetobacter Baumannii(MDRAB). Methods The clinical data of 6 patients with intracranial MDRAB infection admitted in Department of Neurosurgery, The Fourth Cilnical Center, PLA General Hospital from October 1st 2014 to August 1st 2016 were analyzed retrospectively. The results of the appearance, bacteria and drug sensitive test of cerebral spinal fluid(CSF) of these patients were extracted. Based on these results, tigecycline was administered 50 mg 1/12 h intravenously(100 mg for the first administration) companying with some basic treatment. Another 10 mL tigecycline with the concentration of 0.5 mg/mL was administered 1/12 h intrathecally. The therapeutic period was 9-21 days and the average duration was 14 days. The results of the therapy were observed. Results 6 cases of intracranial MDRAB infection were cured after treatment. No significant nervous function disorders were observed. The follow-up period was 1 year. During this period, no infection recurrence was observed in these patients. Conclusions The drug resistant rate of tigecycline is low in the clinical practice and tigecycline is more sensitive to MDRAB. But tigecycline is hard to pass through the blood brain barrier. When intracranial MDRAB infection occurred, the effectiveness of tigecycline was not satisfactory for simply venous administration in some cases. Simultaneously intrathecally administration of tigecycline has better effectiveness, and the nervous function disorders due to the drug are minimal. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Chinese
- ISSN :
- 16727770
- Volume :
- 17
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 142043627
- Full Text :
- https://doi.org/10.3969/j.issn.1672-7770.2020.01.020