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Chronic lung disease in preterm infants receiving various modes of noninvasive ventilation at ≤30 weeks' postmenstrual age.
- Source :
-
Journal of Maternal-Fetal & Neonatal Medicine . May2020, Vol. 33 Issue 9, p1466-1472. 7p. - Publication Year :
- 2020
-
Abstract
- Objective: To determine the incidence of chronic lung disease (CLD) in mechanically ventilated infants who were born at <29 weeks' gestational age (GA), extubated to continuous positive airway pressure (CPAP) or nasal intermittent positive pressure ventilation (NIPPV), and treated with CPAP/NIPPV alone, changed to heated humidified high flow nasal cannula (HHHFNC), or exposed to a combination of CPAP/NIPPV and HHHFNC at ≤30 weeks' postmenstrual age (PMA).Study design: Retrospective cohort study of infants born at <29 weeks' GA admitted to tertiary Canadian neonatal intensive care units between 2011 and 2015. Infants were grouped according to the type of noninvasive ventilation they received at ≤30 weeks' PMA: CPAP/NIPPV alone, HHHFNC alone, or a combination of both.Results: Of the 2378 eligible infants, 1091 (46%) were on CPAP/NIPPV alone, 173 (7.3%) were on HHHFNC alone, and 1114 (47%) were on a combination of CPAP/NIPPV and HHHFNC at ≤30 weeks' PMA until weaned to room air or low flow nasal cannula. After adjustment for confounders, infants in both the CPAP/NIPPV (odds ratio [95% confidence interval]; 2.37 [1.18, 4.79]) and Combination (3.47 [2.06, 5.86]) groups had higher odds of developing CLD than infants in the HHHFNC group.Conclusions: Our results demonstrate that infants transitioned to HHHFNC ≤30 weeks' PMA after extubation to CPAP/NIPPV were associated with a lower odds of CLD than infants maintained on CPAP/NIPPV or a combination of CPAP/NIPPV and HHHFNC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PREMATURE infants
*NONINVASIVE ventilation
*CONTINUOUS positive airway pressure
*LUNG diseases
*POSITIVE pressure ventilation
*MECONIUM aspiration syndrome
*AIRWAY (Anatomy)
*ARTIFICIAL respiration
*COMPARATIVE studies
*INTERMITTENT positive pressure breathing
*RESEARCH methodology
*MEDICAL cooperation
*NEONATAL intensive care
*OXYGEN therapy
*RESEARCH
*RESPIRATORY distress syndrome
*EVALUATION research
*NEONATAL intensive care units
*RETROSPECTIVE studies
Subjects
Details
- Language :
- English
- ISSN :
- 14767058
- Volume :
- 33
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Maternal-Fetal & Neonatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 142124908
- Full Text :
- https://doi.org/10.1080/14767058.2018.1519798