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18F-FDG uptake velocity but not uptake level is associated with progression of carotid plaque.
- Source :
-
European Radiology . Apr2020, Vol. 30 Issue 4, p2403-2411. 9p. 1 Diagram, 3 Charts, 5 Graphs. - Publication Year :
- 2020
-
Abstract
- <bold>Objectives: </bold>The objective of this study was to evaluate whether baseline 18F-fluorodeoxyglucose (FDG) uptake is associated with carotid plaque progression.<bold>Methods: </bold>A total of 156 subjects with carotid plaque were enrolled and underwent carotid magnetic resonance imaging (MRI) (at baseline and the 12-month follow-up) and positron emission tomography-computed tomography (PET-CT) (baseline). Carotid plaque progression was evaluated by two indices (the incidence of plaque progression and percentage of plaque increase) with three-dimensional (3D) imaging, while the 18F-FDG uptake was evaluated by the 18F-FDG uptake levels and 18F-FDG uptake velocity. The association between plaque progression and 18F-FDG uptake was investigated by the trend test and multivariate logistic regression analysis.<bold>Results: </bold>Of the 156 subjects, 80 (51.3%) showed carotid plaque progression during the 12-month follow-up. Firstly, no association was found between 18F-FDG uptake levels and plaque progression. Secondly, significant differences in the incidence of plaque progression were observed among the groups with different uptake velocities, showing a significant decreasing trend ranging from high to intermediate to low (p = 0.002, trend test). After adjusting for covariates, an adequate prediction of the 18F-FDG uptake velocity for the incidence of plaque progression was revealed (OR = 0.682, p < 0.05). In addition, no association was found between the 18F-FDG uptake velocity and the percentage of plaque increase in the subjects with plaque progression (p = 0.757, trend test).<bold>Conclusions: </bold>Our findings suggest 18F-FDG uptake velocity is independently associated with the incidence of carotid plaque progression. Additionally, the 18F-FDG uptake velocity, as another important parameter of PET-CT, warrants further study in future clinical research.<bold>Key Points: </bold>• The18F-FDG uptake levels were not associated with the carotid plaque progression. • The18F-FDG uptake velocity could predict the incidence of carotid plaque progression. • The18F-FDG uptake velocity with related factors warrants more attention in future clinical research. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATHEROSCLEROTIC plaque
*POSITRON emission tomography
*VELOCITY
*MAGNETIC resonance imaging
*LOGISTIC regression analysis
*DISEASE progression
*CAROTID artery diseases
*DISEASE incidence
*ATHEROSCLEROSIS
*RADIOPHARMACEUTICALS
*RESEARCH funding
*HEMODYNAMICS
*DEOXY sugars
*BLOOD flow measurement
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 30
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 142141866
- Full Text :
- https://doi.org/10.1007/s00330-019-06535-8