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WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury.
- Source :
-
International Journal of Molecular Sciences . Feb2020, Vol. 21 Issue 4, p1463. 1p. - Publication Year :
- 2020
-
Abstract
- The treatment of traumatic brain injury (TBI) remains a challenge due to limited knowledge about the mechanisms underlying neuronal regeneration. This current study compared the expression of WNT genes during regeneration of injured cortical neurons. Recombinant WNT3A showed positive effect in promoting neuronal regeneration via in vitro, ex vivo, and in vivo TBI models. Intranasal administration of WNT3A protein to TBI mice increased the number of NeuN+ neurons without affecting GFAP+ glial cells, compared to control mice, as well as retained motor function based on functional behavior analysis. Our findings demonstrated that WNT3A, 8A, 9B, and 10A promote regeneration of injured cortical neurons. Among these WNTs, WNT3A showed the most promising regenerative potential in vivo, ex vivo, and in vitro. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BRAIN injuries
*WNT genes
*NEUROGLIA
*FUNCTIONAL analysis
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 142170117
- Full Text :
- https://doi.org/10.3390/ijms21041463