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The Laboratory Role in anti-TNF Biological Therapy Era.
- Source :
-
Immunological Investigations . Apr2020, Vol. 49 Issue 3, p317-332. 16p. - Publication Year :
- 2020
-
Abstract
- Along years, the advent of biological therapy widely modified treatment of rheumatic diseases and other disorders. However, many agents may elicit in anti-drug antibodies (ADAbs) upon consecutive infusions, with a loss of response. For the right strategy of a personalized medicine, the therapeutic monitoring of TNF-α inhibitors and ADAbs represents an important effort in diagnostic–therapeutic pathway, to improve overall patient management and favoring an appropriate clinical approach. A raising number of diagnostic tests have been designed to elucidate the efficacy and/or safety of a specific drug or class of drugs for a targeted patient's group. Our paper reviewed the current understanding of the immunogenicity of biological drugs employed in the treatment of inflammatory diseases underlying the laboratory role. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOTHERAPY
*DISEASES
*RHEUMATISM
*INDIVIDUALIZED medicine
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 08820139
- Volume :
- 49
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunological Investigations
- Publication Type :
- Academic Journal
- Accession number :
- 142247261
- Full Text :
- https://doi.org/10.1080/08820139.2019.1637434