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Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells.
- Source :
-
Journal of Asian Natural Products Research . May2020, Vol. 22 Issue 5, p452-463. 12p. - Publication Year :
- 2020
-
Abstract
- The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25–150 μM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25–100 μM) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 22
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 142336474
- Full Text :
- https://doi.org/10.1080/10286020.2019.1585820