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cAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer.
- Source :
-
Chemical Communications . 3/21/2020, Vol. 56 Issue 23, p3425-3428. 4p. - Publication Year :
- 2020
-
Abstract
- Inspired by biological nanochannels, a novel cyclic 3′,5′-adenosine monophosphate (cAMP)-regulated artificial nanochannel based on a tripeptide Arg-Thr-Ala (RTA) design is developed. Highly specific binding between the tripeptide and cAMP triggers an obvious conformational transition of a smart polymer chain from a contracted state to a swollen one, which leads to a dynamic modulation of the gating behaviours of the nanochannels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 142337551
- Full Text :
- https://doi.org/10.1039/c9cc09588h