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One-pot four-component synthesis of polysubstituted thiazoles via cascade Ugi/Wittig cyclization starting from odorless Isocyano(triphenylphosphoranylidene)-acetates.
- Source :
-
Tetrahedron . Apr2020, Vol. 76 Issue 15, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1 , aldehydes 2 , amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5 - disubstituted thiazoles 6 in good yields as well. Image 1 • One-pot four-component reactions. • Mild reaction conditions. • Good yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMMONIUM acetate
*THIAZOLES
*WITTIG reaction
*ALDEHYDES
*TRIETHYLAMINE
*ACETATES
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 76
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 142342428
- Full Text :
- https://doi.org/10.1016/j.tet.2020.131101