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Risk factors and clinical features of paroxysmal sympathetic hyperactivity after spontaneous intracerebral hemorrhage.

Authors :
Li, Zhenxing
Chen, Wen
Zhu, Yibai
Han, Kaiwei
Wang, Junyu
Chen, Jigang
Zhang, Danfeng
Yu, Mingkun
Lv, Liquan
Hou, Lijun
Source :
Autonomic Neuroscience: Basic & Clinical. May2020, Vol. 225, pN.PAG-N.PAG. 1p.
Publication Year :
2020

Abstract

Paroxysmal sympathetic hyperactivity (PSH) is a rare complication of spontaneous intracerebral hemorrhage (ICH).We aimed to evaluate the risk factors and clinical features for PSH after ICH. From January 1, 2013 to April 1, 2018, patients with ICH were consecutively included in this observational study. Baseline characteristics were compared in patients with and without PSH. Multivariate logistic regression analysis was used to determine the risk factors associated with PSH development. Clinical features of patients with PSH were also analyzed. There were 548 patients with ICH included and a total of 15 (2.7%) patients were identified with PSH. In univariate analysis, PSH development was associated with the following: previous hemorrhagic stroke, pupils abnormity, admission Glasgow Coma Scale (GCS) score, hematoma volume, liver function abnormity, neutrophil count and early tracheostomy. Multivariate logistic regression analysis showed that a significantly increased risk of PSH was found in patients with previous hemorrhagic stroke (odds ratio [OR], 4.176; 95% confidence interval [CI], 1.111–15.698), admission GCS score (OR, 0.703; 95% CI, 0.548–0.902) and early tracheostomy (OR, 8.317; 95%CI, 1.755–39.412).The most common symptoms of PSH were hyperthermia (80%) and hyperhidrosis (80%).The median Intensive Care Unit stays and Glasgow Outcome Scale at discharge were 34 (19–46) and 2 (1.5–3), respectively. PSH is characterized by a cluster of symptoms and abnormal vital signs, which may lead to poor outcomes in ICH. The present study suggests that previous hemorrhagic stroke, admission GCS score and early tracheostomy may be the significant risk factors for PSH after ICH. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15660702
Volume :
225
Database :
Academic Search Index
Journal :
Autonomic Neuroscience: Basic & Clinical
Publication Type :
Academic Journal
Accession number :
142363651
Full Text :
https://doi.org/10.1016/j.autneu.2020.102643