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Treatment with leucine stimulates the production of hepatocyte growth factor in vivo
- Source :
-
Biochemical & Biophysical Research Communications . Sep2004, Vol. 322 Issue 3, p772-777. 6p. - Publication Year :
- 2004
-
Abstract
- Hepatocyte growth factor (HGF) has pleiotropic effects. Up-regulation of HGF activity in vivo may be beneficial. Branched-chain amino acids (BCAAs) are known to modulate various cellular functions. When starved rats received intraperitoneal injections of valine, leucine or isoleucine, only leucine treatment increased both hepatic and circulating levels of HGF in a dose-dependent manner, up to 1.5 and 2.3 times higher, respectively, than in controls. When young growing rats with free access to food were injected with leucine once a day for a week, HGF levels and liver weights were significantly higher than those of control rats. Furthermore, 1 week of leucine treatment of adult rats resulted in elevated serum albumin levels with an increase in HGF levels. Taken together with our previous report showing that leucine stimulates HGF production by hepatic stellate cells in culture, leucine, among BCAAs, may induce an increase in HGF production by the liver in vivo. [Copyright &y& Elsevier]
- Subjects :
- *BRANCHED chain amino acids
*CYTOKINES
*HEMATOPOIETIC growth factors
*IMINO acids
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 322
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 14247469
- Full Text :
- https://doi.org/10.1016/j.bbrc.2004.07.191