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Increased seizure threshold and severity in young transgenic CRND8 mice
- Source :
-
Neuroscience Letters . Sep2004, Vol. 367 Issue 2, p164-167. 4p. - Publication Year :
- 2004
-
Abstract
- Reports suggest that Alzheimer’s disease (AD) patients show a high life-time prevalence of seizure-like disorders. The transgenic CRND8 (TgCRDN8) is a mouse model of AD-like amyloid pathogenesis that expresses a double-mutant form of human amyloid precursor protein 695 (K670N/M671L and V717F). We have previously reported that post-plaque TgCRND8 mice exhibited a lower threshold to seizure with a more severe seizure type when challenged with pentylenetetrazole (PTZ) intravenously. Here, we now report that pre-plaque TgCRND8 mice also demonstrate an increased sensitivity to PTZ-induced seizures with a more severe seizure type over age-matched littermate controls. A lower threshold and more severe seizure type in TgCRND8 mice prior to and after plaque deposition suggest that this genotype difference may be due to beta-amyloid (Aβ) toxicity rather than plaque formation. Thus, the TgCRND8 mice are not only a model for Aβ production and plaque deposition, but may also be useful for AD associated seizure. [Copyright &y& Elsevier]
- Subjects :
- *SPASMS
*GENETIC research
*ALZHEIMER'S disease
*AMYLOID beta-protein
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 367
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 14250048
- Full Text :
- https://doi.org/10.1016/j.neulet.2004.05.107