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Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan1.

Authors :
Chi-Jung Wu
Wei-Lun Liu
Chih-Cheng Lai
Chien-Ming Chao
Wen-Chien Ko
Hsuan-Chen Wang
Ching-Tzu Dai
Ming-I Hsieh
Pui-Ching Choi
Jia-Ling Yang
Yee-Chun Chen
Wu, Chi-Jung
Liu, Wei-Lun
Lai, Chih-Cheng
Chao, Chien-Ming
Ko, Wen-Chien
Wang, Hsuan-Chen
Dai, Ching-Tzu
Hsieh, Ming-I
Choi, Pui-Ching
Source :
Emerging Infectious Diseases. Apr2020, Vol. 26 Issue 4, p806-809. 4p.
Publication Year :
2020

Abstract

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*ASPERGILLUS fumigatus
*DRUG resistance in microorganisms
*ASPERGILLOSIS
*ANTIFUNGAL agents
*PROTEINS
*RESEARCH
*HETEROCYCLIC compounds
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*ASPERGILLUS
*MICROBIAL sensitivity tests
*PHARMACODYNAMICS

Details

Language :
English
ISSN :
10806040
Volume :
26
Issue :
4
Database :
Academic Search Index
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
142564860
Full Text :
https://doi.org/10.3201/eid2604.190840
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