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Prognostic value of NT-proBNP in patients with severe COVID-19.
- Source :
-
Respiratory Research . 4/15/2020, Vol. 21 Issue 1, p1-7. 7p. 1 Diagram, 3 Charts, 2 Graphs. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.<bold>Methods: </bold>The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.<bold>Results: </bold>The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.<bold>Conclusion: </bold>NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.<bold>Trial Registration: </bold>ClinicalTrials, NCT04292964. Registered 03 March 2020. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*COVID-19 pandemic
*SARS disease
*BIOMARKERS
*CHI-squared test
*CONFIDENCE intervals
*CLINICAL pathology
*EPIDEMICS
*PEPTIDE hormones
*PROBABILITY theory
*REFERENCE values
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*DATA analysis
*PREDICTIVE tests
*PROPORTIONAL hazards models
*RETROSPECTIVE studies
*RECEIVER operating characteristic curves
*DATA analysis software
*DESCRIPTIVE statistics
*HOSPITAL mortality
*KAPLAN-Meier estimator
*LOG-rank test
*MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 14659921
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Respiratory Research
- Publication Type :
- Academic Journal
- Accession number :
- 142737887
- Full Text :
- https://doi.org/10.1186/s12931-020-01352-w