Comment on the paper entitled "high serum concentration of estradiol may be a risk factor of prostate enlargement in aging male in China".

Dear Editor, With the great interest in the recent-online article entitled "High serum concentration of estradiol may be a risk factor of prostate enlargement in aging male in China", we found some significant question that need to discuss [[1]]. The authors in the paper found that serum estradiol (E2) levels in the patients with larger prostate volume was also significantly high than these with smaller prostate volume [[1]]. [Extracted from the article]