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Recent Advances in the Construction of Trifluoromethyl‐Containing Spirooxindoles through Cycloaddition Reactions.
- Source :
-
Chemistry - An Asian Journal . 4/17/2020, Vol. 15 Issue 8, p1225-1233. 9p. - Publication Year :
- 2020
-
Abstract
- The spirooxindole unit is one of the most widely investigated compound skeletons existing in numerous natural and pharmaceutical molecules. Thus, a large number of synthetic methodologies have already been reported to construct such a core structure. The trifluoromethyl group is another privileged unit in organic chemistry. The introduction of a CF3 group to an organic framework can significantly improve the properties of the molecule. In this context, an efficient approach for the construction of trifluoromethyl‐containing spirooxindoles becomes a promising research direction among communities of industry and academia. In this Minireview, recent advances in the construction of trifluoromethyl‐containing spirooxindoles have been summarized and discussed. In addition, representative synthetic methodologies and the corresponding reaction mechanisms have been described as well. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*ORGANIC chemistry
*CONSTRUCTION
Subjects
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 15
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 142811427
- Full Text :
- https://doi.org/10.1002/asia.202000054