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Synthesis and biological evaluation of a MraY selective analogue of tunicamycins.
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . 2020, Vol. 39 Issue 1-3, p349-364. 16p. - Publication Year :
- 2020
-
Abstract
- Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOSYNTHESIS
*NATURAL products
*ORGANIC chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 39
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 142849321
- Full Text :
- https://doi.org/10.1080/15257770.2019.1649696