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Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning.
- Source :
-
International Journal of Biological Macromolecules . Jun2020, Vol. 152, p68-76. 9p. - Publication Year :
- 2020
-
Abstract
- New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the core section was a drug reservoir. With ethyl cellulose and ketoprofen as a filament-forming polymeric matrix and a model drug, respectively, a triaxial electrospinning apparatus was developed to conduct both coaxial and triaxial processes, by which monolithic nanofibers F1 and core-shell nano depots F2 were successfully prepared. Although both of them had the same double components, their different nanostructures generated considerable differences in providing drug sustained release profiles. The core-shell nanofiber depots F2 were able to provide a better zero-order drug release profile: no initial burst release, smooth sustained release effect, and smaller tailing-off release for a nice zero-order drug release kinetics. The release percentage (Q) can be linearly manipulated through the release time (t) according to the equation Q 2 = 9.40 + 4.74 t (R = 0.9936), providing opportunity for precise administration. The developed strategy and advanced electrospinning technique exhibit a new way for constructing process-structure-performance relationships at nano scale and for expanding the potential applications of biological macromolecules in the applied fields. Unlabelled Image • An ethyl cellulose based core-shell structural drug nanodepot • A modified triaxial electrospinning for preparing the depots • The depots have a drug distribution with a drug reservoir in a medicated shell. • The depots provided a zero-order drug sustained release profile. • An obvious process-nanostructure-performance relationship is exhibited. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ETHYLCELLULOSE
*BIOMACROMOLECULES
*PHARMACOKINETICS
*ELECTROSPINNING
Subjects
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 152
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 142930483
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.02.239