İdiopatik Parkinson Hastalığında Tiyol-disülfid Homeostazisi.

Aim: Idiopathic Parkinson's Disease (PD) is a neurodegenerative disease caused by progressive neuronal degeneration in specific locations of the central nervous system. The organisms have developed complex antioxidant systems to regulate the effects and eliminate the damage of free radicals, which plays a role in the etiology of many neurodegenerative diseases. Oxidative stress is thought to play a pathophysiological role in PD. In this study, it was aimed to explore the role of dynamic thiol-disulfide homeostasis as an oxidative stress marker in PD pathophysiology as well as its relation with the characteristics of the disease. Material and Method: The study was conducted with 36 PD patients and 22 healthy individuals. Total Thiol (TT) (μmol/L) and Native Thiol (NT) (μmol/L) were measured, total thiols were mea- sured, and thiol/disulfide balance was detected as a new oxidative marker. Results: NT values were found lower in PD group (p<0.05). NT and TT levels were found in (-) relation with UPDRS scores similar to TT level relation with H-Y stage (p<0.05). Conclusion: Based on these findings indicating that thiol-disulfide homeostasis is disrupted in favor of the oxidative process, the importance of this mechanism in both PD pathophysiology and progress can be emphasized. [ABSTRACT FROM AUTHOR]