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Resistance Exercise–induced Regulation of Muscle Protein Synthesis to Intraset Rest.
- Source :
-
Medicine & Science in Sports & Exercise . May2020, Vol. 52 Issue 5, p1022-1030. 9p. - Publication Year :
- 2020
-
Abstract
- During a traditional set configuration of resistance exercise (TRD), characterized by a continuous completion of repetitions, a decrease in power output tends to occur throughout a set of repetitions. Inclusion of intraset rest, otherwise known as a cluster set configuration (CLU), counteracts this power decline. However, the effect of a CLU configuration on postexercise myofibrillar protein synthesis rates (MPS) and anabolic signaling has not been investigated. Purpose: We aimed to determine if any mechanistic differences exist between TRD and CLU signaling events associated with muscle anabolism. Methods: In randomized crossover trials, eight resistance-trained participants (23 ± 1 yr, 81 ± 4.7 kg, body fat: 18% ± 1.9%; 1 repetition maximum [1RM], 150 ± 9.1 kg) performed an acute bout of CLU (4 sets × (2 × 5) repetitions, 30-s intraset rest, 90-s interset rest) and TRD (4 sets × 10 repetitions, 120-s interset rest) barbell back squats at approximately 70% 1RM with total volume load equated during primed continuous l -[ ring -13C6]phenylalanine infusions. Blood and muscle biopsy samples were collected at rest and after exercise at 0, 2, and 5 h. Results: There was no difference in postexercise MPS between the CLU and TRD condition (P > 0.05) and no changes in phosphorylation of mTORC1 downstream targets (p70S6K and 4EBP1). Total and phosphorylated yes-associated protein on Ser127 transiently increased (P < 0.01) immediately after exercise (t = 0) in CLU (~2.1-fold) and TRD condition (~2.2-fold). Conclusions: Our results show that CLU is a viable anabolic option by preserving power output with similar MPS stimulation when compared with the TRD condition in trained young adults. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD testing
*MUSCLE protein metabolism
*BIOMECHANICS
*BIOPSY
*BLOOD collection
*CELLULAR signal transduction
*COMPARATIVE studies
*CROSSOVER trials
*EXERCISE equipment
*EXERCISE physiology
*EXERCISE tests
*INTRAVENOUS therapy
*METABOLISM
*MUSCLE strength
*PHENYLALANINE
*PHOSPHORYLATION
*RELAXATION for health
*STATISTICAL sampling
*MITOGEN-activated protein kinases
*BODY movement
*RANDOMIZED controlled trials
*PRE-tests & post-tests
*SKELETAL muscle
*DESCRIPTIVE statistics
*RESISTANCE training
Subjects
Details
- Language :
- English
- ISSN :
- 01959131
- Volume :
- 52
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Medicine & Science in Sports & Exercise
- Publication Type :
- Academic Journal
- Accession number :
- 142947626
- Full Text :
- https://doi.org/10.1249/MSS.0000000000002213