Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro.

Authors :: Kwan, Jennifer A.
Schulze, Costas J.
Wang, Wenjie
Leon, Hernando
Sariahmetoglu, Meltem
Sung, Miranda
Sawicka, Jolanta
Sims, David E.
Sawicki, Grzegorz
Schulz, Richard
Source :: FASEB Journal. Apr2004, Vol. 18 Issue 6, p690-692. 3p. 3 Diagrams.
Publication Year :: 2004
Abstract: Deals with a study which characterized the presence of nuclear matrix metalloproteinase-2 (MMP-2) activity and hypothesize that its role may include degradation of the nuclear matrix protein poly (ADP-ribose) polymerase (PARP). Determination of the subcellular localization of MMP-2; Comparison of the amino acid sequence of bovine PARP with various MMP-2 cleavage recognition sequences.

Subjects :: *NUCLEAR matrix
*METALLOPROTEINASES
*POLY(ADP-ribose) polymerase
*TRANSFERASES
*PROTEINASES

Full Text Access

Tools