Evaluation of fermented date palm seed meal with Aspergillus oryzae on the growth, digestion capacity and immune response of Nile tilapia (Oreochromis niloticus).

Five diets were prepared to include date palm seed meal (DSM) fermented with Aspergillus oryzae (ASP) at 0, 50, 100, 150 and 200 g/kg diet and fed for Nile tilapia (26.93 ± 0.01 g) for 8 weeks. Fermented DSM significantly affected the final weight, weight gain and specific growth rate in a dose‐dependent manner (p =.001) with insignificant differences in feed conversion ratio (p >.05). Dietary fermented DSM significantly increased the lipase, amylase and protease activities (p =.008, p =.001 and p =.01, respectively) and the Hb, RBCs and WBCs (p =.001, p =.005, and p =.009, respectively). The intestinal villus length and number of goblet cells were significantly affected by fermented DSM inclusion (p <.05). Additionally, the total protein, albumin and globulin significantly affected by the inclusion of fermented DSM in a dose‐dependent manner (p =.04, p =.045, and p =.03, respectively). Furthermore, dietary fermented DSM significantly altered the phagocytic index, phagocytic activity and lysozyme activity (p =.001, p =.045 and p =.04, respectively). Based on the polynomial regression analysis, the inclusion of fermented DSM at 103.3–164.8 g/kg diet can be used effectively in tilapia diets for improving the growth, digestion activity and immune response. [ABSTRACT FROM AUTHOR]