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Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.
- Source :
-
Science Advances . 5/1/2020, Vol. 6 Issue 18, p1-10. 10p. - Publication Year :
- 2020
-
Abstract
- The article discusses a research examining efficacy of anti–PD-1/PD-L1 therapy in nonresponding cancer patients. It mentions that genetic or pharmacological inhibition of Vps34 kinase activity using SB02024 or SAR405 (Vps34i) decreased the tumor growth and improved mice survival in multiple tumor models. It also mentions that inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy.
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 6
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 143147846
- Full Text :
- https://doi.org/10.1126/sciadv.aax7881