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Effect of venlafaxine dosage, valproic acid concentration, sex, and age on steady state dose‐corrected concentrations of venlafaxine and O‐desmethylvenlafaxine: A retrospective analysis of therapeutic drug monitoring data in a Chinese population
- Source :
-
Human Psychopharmacology: Clinical & Experimental . May2020, Vol. 35 Issue 3, p1-10. 10p. - Publication Year :
- 2020
-
Abstract
- Purpose This study aimed to investigate the influence of diagnosis, body weight, sex, age, smoking, formulations, and concomitant drugs on steady‐state dose‐corrected serum concentrations (C/D) of venlafaxine (VEN) and O‐desmethylvenlafaxine (ODV). Methods: A retrospective analysis of therapeutic drug monitoring (TDM) was carried out. Patients' demographic data, therapeutic regimens, and concentrations were collected. Results: We included 91 verified samples from 80 patients. Females had by average 13% smaller body weight, 50% higher C/D of VEN, and VEN + ODV and 25% smaller ODV/VEN than males. Patients >60 years had by average 33–59% higher C/D levels of ODV and VEN + ODV than younger patients. The concomitant use of valproic acid caused an average 51% higher C/D of ODV and a 2.2‐fold larger ODV/VEN, while clozapine was related with 40% smaller ratio of ODV/VEN and 38% lower C/D levels of ODV. Positive correlations were detected between valproic acid concentrations and the C/D of VEN and VEN + ODV. In a multiple linear regression analysis, variance in the C/D of VEN + ODV was partly attributed to the daily dose of VEN, sex, age and valproic acid concentration. Conclusion: Our results suggested daily dose of VEN, sex, age, and valproic acid as indicators for the C/D of VEN + ODV in Chinese patients. TDM as a valuable tool was suggested in elderly female patients and patients receiving polypharmacy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08856222
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Human Psychopharmacology: Clinical & Experimental
- Publication Type :
- Academic Journal
- Accession number :
- 143150622
- Full Text :
- https://doi.org/10.1002/hup.2733