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Palladium-Catalyzed Cascade Synthesis of Novel Quinolone- Bis(indolyl)methane Hybrids as Promising α-Glucosidase Inhibitors.
- Source :
-
Synthesis . 2020, Vol. 52 Issue 11, p1680-1686. 7p. - Publication Year :
- 2020
-
Abstract
- An unexpected cascade reaction is developed for the construction of functionalized 3-bis(indol-3-yl)methylquinoline-2(1 H)-ones. Three C–C bonds and one ring are created in one pot triggered by Pd-catalyzed C-3 alkenylation of indole with 2-acyl- N -acrylaniline derivatives. A series of complex and specific quinoline-2(1 H)-ones were produced, most of them showed significant α-glucosidase inhibitory activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALKENYLATION
*PALLADIUM
*POTS
*CONSTRUCTION
*INDOLE
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 52
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 143191103
- Full Text :
- https://doi.org/10.1055/s-0039-1690871