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The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1.

Authors :
Peng Sang
Zhihong Zhou
Yan Shi
Candy Lee
Amso, Zaid
Huang, David
Odom, Timothy
Nguyen-Tran, Vân T. B.
Weijun Shen
Jianfeng Cai
Source :
Science Advances. 5/15/2020, Vol. 6 Issue 20, p1-7. 7p.
Publication Year :
2020

Abstract

The article explores how alpha-helix protein structure mimics develop necessities for the retention of natural amino acid residues to maintain their biological activity. It reports the exploration of helical peptides with entire unnatural backbones for their ability to structurally and functionally mimic glucagon-like peptide one.

Details

Language :
English
ISSN :
23752548
Volume :
6
Issue :
20
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
143259113
Full Text :
https://doi.org/10.1126/sciadv.aaz4988