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Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis.

Authors :
Sun, Yi
Zou, Yun
Wang, Lizhen
Gu, Hao
Cen, Qingqing
Chen, Hui
Lin, Xiaoxi
Cai, Ren
Source :
Hereditas. 5/19/2020, Vol. 157 Issue 1, p1-5. 5p.
Publication Year :
2020

Abstract

Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is necessary to estimate and monitor the risk of malignant transformation for giant CMNs. To date, the clinical "ABCD" criteria and immunohistochemistry studies can be confusing and, to some extent, subjective. Accordingly, the elucidation of genomic analyses of nevi is required to better understand the malignant transformation of CMNs. Here, we describe two large to giant CMNs of the scalp with opposite clinical-histological and molecular evaluations of potential malignancy risk. To our knowledge, this is the first description of a genetic study of large to giant CMNs of the scalp in East Asia. We recommend reviewing the molecular diagnosis together with careful medical history and histological information to facilitate the evaluation of the potential malignancy risk. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00180661
Volume :
157
Issue :
1
Database :
Academic Search Index
Journal :
Hereditas
Publication Type :
Academic Journal
Accession number :
143328738
Full Text :
https://doi.org/10.1186/s41065-020-00133-1