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Long-term outcome of surgical resection in patients with gastroenteropancreatic neuroendocrine neoplasia: results from a German nation-wide multi-centric registry.
- Source :
-
Langenbeck's Archives of Surgery . Mar2020, Vol. 405 Issue 2, p145-154. 10p. - Publication Year :
- 2020
-
Abstract
- Background: Neuroendocrine neoplasia (NEN) are rare and heterogenous tumours. Few data exist on the impact of surgical therapy. Materials and methods: This is a retrospective analysis of prospectively collected data of gastroenteropancreatic NEN in the German NET-Registry (1999–2012). It focuses on patients without distant metastases (limited disease, LD, stage I–IIIB). Results: Data of 2239 patients with NEN were recorded. Median age was 59 years, the gender ratio was 1:1.3 (f:m). A total of 986 patients (44%) had LD, and the 5-year survival rate (5 years) was 77% for all and 90% for patients with LD. A total of 1635 patients (73%) received a surgical therapy (1st to 6th line); the 5 and 10 ysr were 83/65% after and 59/35% without surgery for all patients (p <.001). The resection margins in the LD patients were 76%, 16%, and 3% for R0, R1 and R2, respectively. The 10 ysr was 84%, 59% and 42% for R0, R1 and R2 resections, respectively (p =.021 R0/R1, p <.001 R0/R2). The R0 resection rate was 75% for G1/G2 NET and 67% for G3 NEC. Conclusion: The rate of complete tumour resection (R0) in LD is independent of tumour grading, and R0 resection is the key determinant of long-term survival, as demonstrated by the 10 ysr. of 84%. All NEN patients with limited disease should be considered for operation, if possible, as the best 10-year survival is shown after an R0 resection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SURGICAL excision
*INSECTICIDE-treated mosquito nets
*MOSQUITO nets
Subjects
Details
- Language :
- English
- ISSN :
- 14352443
- Volume :
- 405
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Langenbeck's Archives of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 143359770
- Full Text :
- https://doi.org/10.1007/s00423-020-01868-1