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Integrated individually electrochemical array for simultaneously detecting multiple Alzheimer's biomarkers.
- Source :
-
Biosensors & Bioelectronics . Aug2020, Vol. 162, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Simultaneous detection of multiple biomarkers is benefit for reducing the detection cycles, avoiding the false-positive signals, and providing the cross validation, which provide the opportunity to understand the pathogenic mechanisms and achieve precise early diagnosis. Here, we demonstrate the mini-pillar-based individual electrochemical array for simultaneous detection of multiple biomarkers. On such platform, the mini-pillar could confine the microdroplet as individual and open-channel microreactor, which is extremely helpful for reducing reagent consumption and extracting internal information, and the electrodes array embedded in mini-pillar are integrated on one side to achieve multiple and simultaneous electrochemical sensing. The introduction of gold nanodendrites by electrodeposition has greatly enhanced sensitivity via improving probe-binding capacity and response signals. Sensitive and selective detection of multiple Alzheimer's biomarkers including Tau, ApoE4, Amyloid-β and miRNA-101 on such mini-pillar-based biosensor is also achieved. Such biosensor platform with the advantages of high-yield, high sensitivity, low-waste and multiple signals output shows great promise in sensing multiple biomolecules for disease diagnosis and health monitoring. • An integrated mini-pillar-based electrochemical sensor is designed. • The optimal gold nanodendrites electrode has the high sensitivity and stability toward electrochemical sensing. • Multiple Alzheimer's biomarkers have been simultaneously detected on such mini-pillar-based electrochemical sensor. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ELECTROCHEMICAL sensors
*GOLD electrodes
*EARLY diagnosis
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 162
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 143365265
- Full Text :
- https://doi.org/10.1016/j.bios.2020.112253