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Development of metformin hydrochloride loaded dissolving tablets with novel carboxymethylcellulose/poly-l-lysine/TPP complex.
- Source :
-
International Journal of Biological Macromolecules . Jul2020, Vol. 155, p411-420. 10p. - Publication Year :
- 2020
-
Abstract
- Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly- l -lysine/tripolyphosphate (CMC/PLL/TPP) complex, were prepared using metformin hydrochloride (MetHCl) as model drug. Confocal laser scanning microscopy observation manifested that FITC-labeled PLL interacted with CMC and formed a uniform interior microstructure. Scanning electron microscope images showed the drug-loaded tablets had well-formed shapes with smooth surfaces. MetHCl embedded interior the microstructures of the tablets and represented in a crystal form. Thermo-gravimetric analysis and differential scanning calorimetry indicated that the drug-loaded tablets had stable thermal properties with less moisture content (3.52%). Fourier transform infrared spectrometer confirmed that the CMC/PLL/TPP complex was fabricated via the electrostatic interactions between -NH 3 +, -COO− and -[P 2 O 5 4-]− groups. The drug-loaded tablets had a high drug loading efficiency of 85.76% and drug encapsulation efficiency of 81.47%, and a shorter wetting time of 2.16 min in SSF (pH 6.8) and lower swelling ratio of 233.34%. The drug loaded in the samples could be released completely within 10 min in simulated saliva fluid (SSF pH 6.8), indicating a rapid drug release and dissolving profile in the environment, which could be developed for dissolving tablets. • Novel carboxymethylcellulose/poly- l -lysine/tripolyphosphate tablets were prepared. • FITC-labeled PLL interacted with CMC and formed a uniform interior microstructure. • The drug-loaded tablets had a higher drug loading efficiency of 85.76%. • The drug released completely within 10 min in simulated saliva fluid (SSF pH 6.8). • CMC/PLL/TPP complex could be used to develop dissolving tablets as drug vehicles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 155
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 143383772
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.03.191