基于网络药理学研究女贞子-淫羊藿药对活性成分抗 骨质疏松的分子机制.

Objective To clarify active components in fructus ligustri lucidi-herba epimedii maxim based on network pharmacology, to set up and analyze molecular regulation network consisting of active compounds-targets-pathway involved in antiosteoporosis effect, and to demonstrate the scientific principle of combined use of fructus ligustri lucidi-herba epimedii maxim.Methods The active components in fructus ligustri lucidi-herba epimedii maxim were screened using TCMSP. The effective targets acted by fructus ligustri lucidi-herba epimedii maxim were clarified using Venn diagram by targeting prediction approach combined with bioinformatics. The target signal pathway GO analysis was performed with DAVID after organizing effective targets with network visual software Cytoscape 3.7.1. Results Thirty-three active compounds were obtained from fructus ligustri lucidi-herba epimedii maxim based on OB and DL value from TCMSP,and accordingly 227 action targets were explored. One hundred and ninety targets,highly correlating with osteoporosis, were found through searching from disease targets database. The 12 key pathways, potentially applied for treating osteoporosis, including osteoclasts differentiation and cancer pathway, were identified after KEGG analysis. Conclusion The multiple components contained in herbal pair of fructus ligustri lucidi-herba epimedii maximcould be used in management of osteoporosis with TCM characteristics. [ABSTRACT FROM AUTHOR]