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Clinical remission of ulcerative colitis after different modes of faecal microbiota transplantation: a meta-analysis.
- Source :
-
International Journal of Colorectal Disease . Jun2020, Vol. 35 Issue 6, p1025-1034. 10p. 2 Diagrams, 7 Charts. - Publication Year :
- 2020
-
Abstract
- Background: Ulcerative colitis (UC) is a chronic, recurrent and destructive disease of the gastrointestinal tract. Faecal microbiota transplantation (FMT) is a therapeutic measure in which faecal microbiota from healthy people is transplanted into patients. Aim: To systematically evaluate the safety and effectiveness of treating UC with different modes of FMT. Methods: Seven databases were searched by two independent researchers and studies related to randomized controlled trials were included in the analysis. Results: Seven studies on UC involving 431 patients were included in the analysis. The results showed that FMT had better efficacy than placebo (OR = 2.29, 95% CI 1.48–3.53, P = 0.0002). Subgroup analyses of influencing factors showed that frozen faeces from multiple donors delivered via the lower gastrointestinal tract had a better curative effect than placebo (OR = 2.76, 95% CI 1.59–4.79, P = 0.0003; OR = 2.93, 95% CI 1.67–5.71, P = 0.0002; and OR = 2.70, 95% CI 1.67–4.37, P < 0.0001); the difference in efficacy between mixed faeces from a single donor transplanted through the upper gastrointestinal tract and placebo was not significant(P = 0.05, P = 0.09 and P = 0.98). The analysis of side effects showed no significant difference between FMT and placebo (P = 0.43). Conclusions: It may be safe and effective to transplant frozen faeces from multiple donors through the lower gastrointestinal tract to treat UC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01791958
- Volume :
- 35
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- International Journal of Colorectal Disease
- Publication Type :
- Academic Journal
- Accession number :
- 143397373
- Full Text :
- https://doi.org/10.1007/s00384-020-03599-7