Influence of the Insertion Site on Central Venous Catheter-Related Complications in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation.

• Rates of central line-associated bloodstream infections are the same in internal jugular vein (IJV) and subclavian vein (SCV) central venous catheters (CVCs) after allogeneic hematopoietic cell transplantation (HCT). • The strongest risk factor for local inflammation or fever is >6 neutropenic CVC-days. • The time to local inflammation is longer with CVCs placed in the IJV. • CVC placement in the SCV is not superior to placement in the IJV in allogeneic HCT. • A clear recommendation for a preferred CVC insertion site is not supported in allogeneic HCT. Central venous catheters (CVCs) are extensively used in patients undergoing allogeneic hematopoietic cell transplantation (HCT). In these patients CVC are placed routinely either via the internal jugular vein (IJV) or the subclavian vein (SCV). Purpose of this study was to systematically analyze complications of CVC at different insertion sites in HCT recipients. In this retrospective analysis, all consecutive patients (n = 56) who received a CVC (n = 101) due to allogeneic HCT at our institution between January 2011 and June 2013 were included. Three-lumen standard, nontunneled CVCs were placed via either the IJV (n = 60; 59%) or the SCV (n = 41; 41%). Study endpoints were time to local inflammation at the insertion site, time to fever, time to a combined endpoint of inflammation and fever, central line-associated bloodstream infection (CLABSI), duration of catheterization, catheter lumen obstruction, deep-vein thrombosis, pneumothorax, and catheter-related death. The median duration of catheterization per CVC was almost identical for the IJV and SCV sites (18 days versus 17 days; P not significant). There were no differences in the frequency of CLABSI, deep-vein thrombosis, pneumothorax, and catheter lumen obstruction between IJV and SCV CVC insertion sites. None of the patients died due to a CVC-related cause. Local inflammation occurred less frequently (48% versus 71%; P =.025) and later (median time to local inflammation, 25 days versus 12 days; P =.01) in IJV CVCs versus SCV CVCs. There was a trend toward a median longer time to the occurrence of fever for IJV CVCs compared with SCV CVCs (20 days versus 13 days; P =.07). In the multivariate analysis, diagnosis of acute leukemia (hazard ratio [HR], 1.696; P =.036), SCV CVC (HR, 1.617; P =.039), and neutropenic CVC-days (HR, 2.477; P =.01) were identified as risk factors for the occurrence of local inflammation or fever. In contrast to earlier studies in patients without hematologic malignancies, these data demonstrate that CVCs placed in the SCV are not superior over IJV CVCs. Moreover, local inflammation occurred earlier and more frequently in patients with an SCV CVC. [ABSTRACT FROM AUTHOR]