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Programmed cell death protein 1 on natural killer cells: fact or fiction?
- Source :
-
Journal of Clinical Investigation . Jun2020, Vol. 130 Issue 6, p2816-2819. 4p. 1 Diagram, 1 Chart. - Publication Year :
- 2020
-
Abstract
- Programmed cell death protein 1 (PD-1) has become one of the most investigated targets for cancer immunotherapy. Most research has centered on inhibiting PD-1 on T cells, but there is increased interest in understanding the role of PD-1 on NK cells. While the expression of PD-1 on NK cells has been controversial, with papers publishing contradictory results in multiple models, there is increased clinical interest in NK and PD-1 immunotherapy. In this issue of the JCI, Judge et al. comprehensively explore the lack of PD-1 expression on murine, canine, and human NK cells and the clinical implication of these findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- *APOPTOSIS
*KILLER cells
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 130
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 143527886
- Full Text :
- https://doi.org/10.1172/JCI137051