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Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old.
- Source :
-
BMC Neurology . 6/3/2020, Vol. 20 Issue 1, p1-6. 6p. 2 Charts. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>The aim of this study was to assess the cognitive function of patients over 60 years old with meningioma using a domain-specific neuropsychological test and to investigate the relevant factors affecting pre-operative cognitive decline in different subdomains.<bold>Methods: </bold>We retrospectively investigated 46 intracranial meningioma patients between the ages of 60 and 85 years. All patients underwent brain MRI and neuropsychological test. Tumor size, location, peritumoral edema, and medial temporal atrophy (MTA) were examined to determine the association with cognitive impairment. We performed a logistic regression analysis to examine the odds ratios (ORs) for cognitive decline of four subdomains: verbal memory, language, visuospatial, and executive functions.<bold>Results: </bold>Tumor size and age were associated with executive dysfunction (OR 1.083, 95% confidence interval (CI) 1.006-1.166, and OR 1.209, 95% CI 1.018-1.436, respectively). There was no statistically significant association in other cognitive domains (language, verbal memory, and visuospatial function) with variables in regression analysis.<bold>Conclusions: </bold>We conclude that tumor size and age are positively related with executive function in pre-operative meningioma patients over 60 years old. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COGNITION disorders
*LOGISTIC regression analysis
*NEUROPSYCHOLOGICAL tests
*VERBAL memory
*REGRESSION analysis
*ODDS ratio
*MONTREAL Cognitive Assessment
*ONCOLOGIC surgery
*MEMORY
*EXECUTIVE function
*COGNITION
*RETROSPECTIVE studies
*MAGNETIC resonance imaging
*ATROPHY
*MENINGIOMA
*MENINGES
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 20
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 143571097
- Full Text :
- https://doi.org/10.1186/s12883-020-01806-0