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Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives.
- Source :
-
Phosphorus, Sulfur & Silicon & the Related Elements . 2020, Vol. 195 Issue 6, p491-497. 7p. - Publication Year :
- 2020
-
Abstract
- In this study, a novel series of benzothiazole-thiazolylhydrazine (3a–3i) was synthesized and their structures were characterized by 1H-NMR, 13C-NMR spectrometry, and mass spectroscopy. These compounds were evaluated as inhibitors of type A and type B monoamine oxidase (MAO) enzymes. The most active compound 3b (2-((2-(2-(4-(4-Nitrophenyl)thiazol-2-yl)hydrazineylidene)-2-phenylethyl)thio)benzothiazole) showed strong inhibitory activity at hMAO-A (IC50 of 0.095 ± 0.004 µM). Furthermore, compound 3i (2-((2-(2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazineylidene)-2-phenylethyl)thio)benzothiazole) showed significant inhibition profile on hMAO-A with the IC50 values 0.141 ± 0.006 µM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MONOAMINE oxidase
*MASS spectrometry
*BENZOTHIAZOLE
Subjects
Details
- Language :
- English
- ISSN :
- 10426507
- Volume :
- 195
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Phosphorus, Sulfur & Silicon & the Related Elements
- Publication Type :
- Academic Journal
- Accession number :
- 143611460
- Full Text :
- https://doi.org/10.1080/10426507.2020.1722667