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Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience.
- Source :
-
Journal of Headache & Pain . 6/9/2020, Vol. 21 Issue 1, p1-14. 14p. - Publication Year :
- 2020
-
Abstract
- Background: erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using erenumab in patients with chronic migraine experiencing previous unsuccessful preventive treatments. Methods: Seventy patients with chronic migraine and failure to ≥4 migraine preventive medication classes initially received monthly erenumab 70 mg s.c. Patients without a clinically meaningful improvement, considered as a > 30% reduction in headache days per month, after ≥3 months of therapy switched to monthly erenumab 140 mg. At the first administration and after 3 and 6 months, patients underwent extensive interviews to assess clinical parameters of disease severity and migraine-related disability and impact, and validated questionnaires to explore depression/anxiety, sleep, and quality of life (QoL). Finally, the Pain Catastrophizing Scale, Allodynia Symptom Checklist-12 and MIGraine attacks-Subjective COGnitive impairments scale (MIG-SCOG) were administered. Results: 70% of patients were "responders" after the third administration of erenumab 70 mg, whereas 30% switched to erenumab 140 mg; 29% (6 pts) responded after the sixth administration. The headache-day frequency was reduced from 21.1 ± 0.7 to 11.4 ± 0.9 days after the third administration (p < 0.001) and to 8.9 ± 0.7 days after the sixth administration (p < 0.001). 53% and 70% of patients, respectively, showed a reduction of ≥50% of headache days/month after the third and the sixth administrations. Also improved were headache pain severity, migraine-related disability, and impact on daily living, QoL, pain catastrophizing and allodynia (all p < 0.001), quality of sleep, symptoms of depression or anxiety (p < 0.05) but not MIG-SCOG. There were no new adverse event signals. Conclusion: These real-world data support monthly erenumab 70 or 140 mg s.c. as a safe and effective preventive treatment to reduce headache frequency and severity in chronic migraine patients experiencing previous unsuccessful preventive treatments. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLODYNIA
*ANALGESICS
*ANXIETY
*CHRONIC diseases
*CLINICAL trials
*MENTAL depression
*FUNCTIONAL assessment
*INTERVIEWING
*MIGRAINE
*QUALITY of life
*SLEEP
*ACTIVITIES of daily living
*PAIN measurement
*TREATMENT effectiveness
*PRE-tests & post-tests
*SEVERITY of illness index
*PAIN catastrophizing
*DESCRIPTIVE statistics
*PHARMACODYNAMICS
MIGRAINE complications
Subjects
Details
- Language :
- English
- ISSN :
- 11292369
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Headache & Pain
- Publication Type :
- Academic Journal
- Accession number :
- 143677652
- Full Text :
- https://doi.org/10.1186/s10194-020-01143-0