تاثیرمکمل رزوراترول در بهبود کبد چرب غیرالکلی: مروری بر مطالعات کارآزمایی بالینی

Non-Alcoholic Fatty Liver (NAFLD) is produced by liver pathological accumulation of fat and the prevalence of this disorder in the world is 35-36%. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving nonalcoholic fatty liver. Resveratrol is a polyphenolic compound that has antioxidant properties. Other mechanisms of resveratrol have been shown to improve fatty liver. Study Type: A systematic Review on Randomized Clinical Trials. This study aimed to investigate the results of research on the relationship between supplementation of resveratrol and non-alcoholic fatty liver. Randomized Clinical Trials on the effect of supplementation of resveratrol on NAFLD from PubMed, Scopus, ISI and Google Scholar databases between 2000 and 2018 with the keywords: Resveratrol, Fatty Liver, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NAFLD Reviewed. Between most clinical trials have shown positive effects of resveratrol supplementation on the improvement of non-alcoholic fatty liver symptoms, including oxidative stress, inflammation, liver enzymes, and insulin resistance. There was also a decrease in fat content in the subjects. However, some studies have different results and do not show a significant effect on resveratrol supplementation. In most studies, the positive effects of resveratrol supplementation on non-alcoholic fatty liver have been proven, but more studies are needed because of the controversy of the study. [ABSTRACT FROM AUTHOR]