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In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines.
- Source :
-
South African Journal of Botany . Jul2020, Vol. 131, p295-301. 7p. - Publication Year :
- 2020
-
Abstract
- • The Agavaceae species extracts had promising cytotoxicity against some cancer cells. • Some fractions from P. tuberosa, Y. filamentosa and F. Watsoniana had strong cytotoxicity. • Cytotoxicity shown by extracts may be related to steroidal saponins present. Among the plants which are determined to be a promising source of anticarcenogenic agents are members of Agavaceae family which are common in tropical and subtropical regions such as Egypt. In this study, cytotoxic activity were assessed for the methanolic extracts and fractions from five members of Agavaceae family: Sansevieria cylindrica Bojer., Polianthes tuberosa L., Sansevieria trifasciata Prain., Yucca filamentosa L. and Furcraea watsoniana Hort. against MCF-7 (breast), HepG-2 (hepatoma), and Caco-2 (colon) cancer cell lines by MTT method. The n -hexane fraction of P. tuberosa leaves extract demonstrated strong cytotoxic potential against all three cancer cell lines (CC 50 <20 µg/ml). The ethyl acetate fractions of Y. filamentosa and F. watsoniana leaves significantly inhibited proliferation of hepatocellular HepG-2 (CC 50 = 6.21 µg/ml and 19.07 µg/ml, respectively) and intestinal epithelium Caco-2 carcinoma cells (CC 50 = 18.86 µg/ml and 23.25 µg/ml, respectively). Presumably, the cytotoxic activity exhibited by n -hexane fraction of P. tuberosa , ethyl acetate fractions of Y. filamentosa and F. watsoniana may be related to the steroidal saponins that are present in these samples. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUCCULENT plants
*LIVER cancer
*COLON (Anatomy)
*CANCER cells
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 02546299
- Volume :
- 131
- Database :
- Academic Search Index
- Journal :
- South African Journal of Botany
- Publication Type :
- Academic Journal
- Accession number :
- 143703170
- Full Text :
- https://doi.org/10.1016/j.sajb.2020.02.023