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Serum selenium in critically ill patients: Profile and supplementation in a depleted region.
- Source :
-
Acta Anaesthesiologica Scandinavica . Jul2020, Vol. 64 Issue 6, p803-809. 7p. 1 Diagram, 2 Charts, 3 Graphs. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>General selenium supplementation to intensive care unit (ICU) patients in regions with selenium-rich soil does not improve outcomes. Still selenium supplementation may reduce morbidity and mortality in patients with low-serum selenium concentration (S-Se) in selenium-poor areas who respond to treatment. The primary aim of this observational study was to investigate S-Se in a selenium-deficient region at time of intensive care admission, and in addition to monitor S-Se during high-dose selenium supplementation for safety.<bold>Methods: </bold>We measured S-Se in 100 consecutive patients admitted to a tertiary general ICU. After initial sampling, high-dose intravenous (iv) selenium supplementation was administered up to 20 days.<bold>Results: </bold>At admission, in 95% of the cases, S-Se was below the saturation level for selenoenzymes, in 91%, below the Swedish reference level, and in 71%, below the level where selenoenzyme function may be impaired. At day 5 of substitution, all patients still remaining in the ICU (n = 26) were within the range for enzyme function, 12% were below reference, and 24% did not reach full enzymatic saturation. At day 10 and forward, all patients were within target for treatment. No patients were at risk for toxic S-Se concentration.<bold>Conclusions: </bold>S-Se concentration was substantially lower compared to normal values at ICU admission in this cohort of unselected Swedish critical care patients. Selenium supplementation restituted S-Se to levels corresponding to enzymatic saturation and the Swedish reference interval for all subjects remaining in the ICU on day 5. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SELENIUM
*CRITICALLY ill
*INTENSIVE care units
*RESEARCH funding
Subjects
Details
- Language :
- English
- ISSN :
- 00015172
- Volume :
- 64
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Acta Anaesthesiologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 143719696
- Full Text :
- https://doi.org/10.1111/aas.13573