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Endocannabinoid-Mediated Metaplasticity in the Hippocampus
- Source :
-
Neuron . Sep2004, Vol. 43 Issue 6, p871-881. 11p. - Publication Year :
- 2004
-
Abstract
- Repetitive activation of glutamatergic fibers that normally induces long-term potentiation (LTP) at excitatory synapses in the hippocampus also triggers long-term depression at inhibitory synapses (I-LTD) via retrograde endocannabinoid signaling. Little is known, however, about the physiological significance of I-LTD. Here, we show that synaptic-driven release of endocannabinoids is a highly localized and efficient process that strongly depresses cannabinoid-sensitive inhibitory inputs within the dendritic compartment of CA1 pyramidal cells. By removing synaptic inhibition in a restricted area of the dendritic tree, endocannabinoids selectively “primed” nearby excitatory synapses, thereby facilitating subsequent induction of LTP. This induction of local metaplasticity is a novel mechanism by which endocannabinoids can contribute to the storage of information in the brain. [Copyright &y& Elsevier]
- Subjects :
- *SYNAPSES
*FIBERS
*NEURAL transmission
*HIPPOCAMPUS (Brain)
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Volume :
- 43
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 14373322
- Full Text :
- https://doi.org/10.1016/j.neuron.2004.08.036