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B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
- Source :
-
Immunity (10747613) . Sep2004, Vol. 21 Issue 3, p401-413. 13p. - Publication Year :
- 2004
-
Abstract
- The reported affinity differences between CD28 and CTLA-4 binding to B7-1 and B7-2 may serve to selectively regulate CD28 and CTLA-4 function by differentially recruiting and/or stabilizing these molecules at the immunological synapse. Here we show that ligand binding is important for the accumulation of both CD28 and CTLA-4 at the synapse. While CD28 is recruited to the synapse in the absence of B7-1 and B7-2 binding, it is not effectively stabilized there, as its localization can be disrupted by CTLA-4. In the case of CTLA-4, ligand binding is critical for its concentration at the synapse. We also demonstrate that the affinity and avidity differences in ligand binding translate into selective recruitment of CD28 or CTLA-4 to the immunological synapse—B7-1 is the major ligand mediating CTLA-4 localization, while B7-2 is the main ligand for CD28 concentration at the synapse. [Copyright &y& Elsevier]
- Subjects :
- *SYNAPSES
*NEURAL transmission
*IMMUNOLOGY
*MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 21
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 14373336
- Full Text :
- https://doi.org/10.1016/j.immuni.2004.06.017