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Type 1 interferons as a potential treatment against COVID-19.
- Source :
-
Antiviral Research . Jun2020, Vol. 178, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. • Interferon treatment has shown mixed efficiency against SARS-CoV and MERS-CoV. • SARS-CoV-2 is probably more sensitive to interferon than the other coronaviruses. • The IFNβ subtype appears to be the most suited for COVID-19 treatment. • Interferon treatment should be performed in the early stages of the infection. • Investigation on interferon-based COVID-19 treatment is warranted. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01663542
- Volume :
- 178
- Database :
- Academic Search Index
- Journal :
- Antiviral Research
- Publication Type :
- Academic Journal
- Accession number :
- 143740079
- Full Text :
- https://doi.org/10.1016/j.antiviral.2020.104791