A high pressure effect on the vibrational spectra of ranitidine hydrochloride.

The vibrational spectra of the ranitidine hydrochloride have been studied using Raman spectroscopy at pressures up to 11.2 GPa. At a pressure above 1.2 GPa a polymorphic phase transition from the initial form II to a new pressure induced form V has been observed. The vibration modes of the ranitidine hydrochloride as functions of pressure have been obtained. At pressures above 6.2 GPa, a gradual transformation to the amorphous phase of ranitidine hydrochloride has been revealed. Image 1 • The Raman spectra of ranitidine hydrochloride at high pressure were measured. • The new pressure induced phase of ranitidine hydrochloride has been found. • The pressure driven amorphization of ranitidine hydrochloride has been observed. • The anomalies in the baric dependencies of vibration modes were obtained. [ABSTRACT FROM AUTHOR]